2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-129449
    AnnH31 241809-12-1 99.91%
    AnnH31 is a Dyrk1A inhibitor (IC50: 81 nM). AnnH31 also inhibits MAO-A with an IC50 of 3.2 μM. AnnH31 inhibits cell viability of HeLa, PC12 and SH-SY5Y cells.
    AnnH31
  • HY-129464
    NO-711ME 127586-66-7 98%
    NO-711ME is a prodrug of NO-711. NO-711 is a potent and selective GABA uptake inhibitor.
    NO-711ME
  • HY-129488
    FPFS-1169 hydrochloride 265130-22-1 98%
    FPFS-1169 (hydrochloride) is a proto-oncogene protein c-bcl-2 stimulant. FPFS-1169 (hydrochloride) can increase the impulse-evoked release of monoamine neurotransmitters. FPFS-1169 (hydrochloride) can be studied in research on Parkinson’s disease.
    FPFS-1169 hydrochloride
  • HY-12962A
    NMDA-IN-1 dihydrochloride 1784252-90-9 98%
    NMDA-IN-1 dihydrochloride is a selective NMDA NR2B antagonist with a Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM. NMDA-IN-1 dihydrochloride inhibits Glu/Gly stimulated Ca2+ flux in Ltk- cells expressing the hNR1a/NR2B with a IC50 of 9.7 nM. NMDA-IN-1 dihydrochloride has no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. NMDA-IN-1 dihydrochloride shows excellent activity in the mechanical hyperalgesia assay in rats. NMDA-IN-1 dihydrochloride can be used for the studies of stroke, parkinson, and neuropathic pain.
    NMDA-IN-1 dihydrochloride
  • HY-129661
    AH 7959 763023-14-9 98%
    AH 7959 is an orally active N-substituted cyclohexyl methyl benzamide compound that has analgesic effects, the oral and subcutaneous ED50 of AH 7959 in mice is greater than 100 mg/kg.
    AH 7959
  • HY-129666
    NSC-65847 6949-15-1 98%
    NSC-65847 is a groundbreaking dual inhibitor targeting both viral neuraminidase and Streptococcus pneumoniae neuraminidase.
    NSC-65847
  • HY-129682
    LY125180 74515-39-2 98%
    LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively.
    LY125180
  • HY-129688
    Sut-8701 123577-73-1 98%
    Sut-8701 is a Cholecystokinin (HY-P2932) analog that effectively slows the degenerative process of Alzheimer's disease by protecting the integrity of cholinergic neurons in the nucleus basalis.
    Sut-8701
  • HY-129807
    LY-228729 115994-31-5 98%
    LY-228729 is a selective 5-HT1A receptor agonist. LY-228729 can reduce the rearing frequency of rats and decrease their activity in the central area in the open field test. LY-228729 can reduce the immobility time of rats and increase their swimming time in the forced swim test. LY-228729 can be used in the research of neurological diseases.
    LY-228729
  • HY-12980A
    Batefenterol Succinate 945905-37-3 98%
    Batefenterol Succinate (GSK961081 Succinate) is a first-of-its-kind inhaled bifunctional bronchodilator with smooth muscle relaxant properties. The activities of Batefenterol Succinate include acting as a smooth muscle parasympathetic antagonist and a beta2-adrenoceptor agonist. Batefenterol Succinate is used to improve respiratory function, especially in patients with chronic obstructive pulmonary disease (COPD).
    Batefenterol Succinate
  • HY-129810
    PD 135158 130325-35-8 98%
    PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity.
    PD 135158
  • HY-129822
    5-EAPB hydrochloride 1823776-22-2 98%
    5-EAPB hydrochloride is a benzofuran.
    5-EAPB hydrochloride
  • HY-129850
    4-Chloromethamphetamine hydrochloride 30572-91-9 98%
    4-Chloromethamphetamine hydrochloride is a new psychoactive substance belonging to the amphetamine class.
    4-Chloromethamphetamine hydrochloride
  • HY-129862
    Eclanamine maleate 67450-45-7 98%
    Eclanamine maleate is functionally categorized as a nontricyclic antidepressant.
    Eclanamine maleate
  • HY-129876
    D-NAME hydrochloride 50912-92-0 98%
    D-NAME (D-NG-nitroarginine methyl ester) hydrochloride is a potent nitric oxide synthase (NOS) inhibitor. D-NAME hydrochloride inhibits the activity of NOS, reducing the production of nitric oxide.
    D-NAME hydrochloride
  • HY-129907
    2-AEMP 321882-95-5 98%
    2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-ρ1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 μM, compared to 7 μM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity.
    2-AEMP
  • HY-129947
    (-)-Carveol 1253216-40-8 98%
    (-)-Carveol is a natural unsaturated monocyclic monoterpene alcohol with the activity of regulating neural excitability. (-)-Carveol can activate or inhibit neural excitability by changing its chemical structure, which has potential significance for the design of targeted compounds. (-)-Carveol can also be used as a fragrance in cosmetics and a flavor additive in the food industry.
    (-)-Carveol
  • HY-129954
    6-EAPB hydrochloride 1823318-37-1 98%
    6-EAPB hydrochloride is a benzofuran.
    6-EAPB hydrochloride
  • HY-129980
    NPC-15437 dihydrochloride 141774-20-1 98%
    NPC-15437 dihydrochloride is a selective, penetrable and reversible protein kinase C (PKC) inhibitor, with an IC50 of 19 μM. NPC-15437 dihydrochloride interferes with mechanisms underlying memory consolidation.
    NPC-15437 dihydrochloride
  • HY-129985
    Clovoxamine 54739-19-4 98%
    Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant.
    Clovoxamine
Cat. No. Product Name / Synonyms Application Reactivity